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Effects of Decoction on plasma proteome in cirrhosis: preliminary experimental study with rats
LIU Jie, WANG Jiyao, WEI Liming, LU Ye, Jin Hong
Frontiers of Medicine 2008, Volume 2, Issue 1, Pages 39-44 doi: 10.1007/s11684-008-0008-z
Keywords: Decoction intervention serine/threonine-protein underwent Decoction glutathione peroxidase
Mengjie LI, Chunbao LI, Shangxin SONG, Xinglian XU, Guanghong ZHOU
Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 3, Pages 362-372 doi: 10.15302/J-FASE-2018206
This study compared proteome profiles and morphological changes of rat jejunum in response to differentProteome analysis, histological observation and PEPT1 quantification of the jejunum were performed.
Keywords: Hippo signaling pathway meat protein PEPT1 proteome analysis rat jejunum
Yiming Ma,Ting Xiao,Quan Xu,Xinxin Shao,Hongying Wang
Frontiers of Medicine 2016, Volume 10, Issue 3, Pages 278-285 doi: 10.1007/s11684-016-0453-z
Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. We aimed to find novel molecules as potential biomarkers for the early diagnosis of CRC. A serum-free conditioned medium was successfully collected from three pairs of CRC tissue and adjacent normal tissue. iTRAQ-based quantitative proteomic analysis was applied to compare the differences in secretome between primary CRC mucosa and adjacent normal mucosa. A total of 145 kinds of proteins were identified. Of these proteins, 29 were significantly different between CRC and normal tissue. Tropomyosin 2 β (TPM2) exhibited the most significant differences; as such, this protein was selected for further validation. Quantitative real-time PCR indicated that the mRNA expression of TPM2 significantly decreased in the CRC tissue compared with the paired adjacent normal tissue. Immunohistochemical analysis also confirmed that TPM2 was barely detected at protein levels in the CRC tissue. In summary, this study revealed potential molecules for future biomarker applications and provided an efficient approach for the differential analysis of cancer-associated secretome. TPM2 may be valuable for the early diagnosis of CRC.
Keywords: iTRAQ secretome colorectal cancer TPM2
Frontiers of Medicine Pages 993-1005 doi: 10.1007/s11684-023-0989-7
Keywords: acupuncture migraine fMRI metabolome proteome
Zhengyi Jiang, Zeyu Sun, Xiaoxi Ouyang, Yalei Zhao, Menghao Zhou, Baohong Wang, Qirui Li, Linxiao Fan, Sainan Zhang, Lanjuan Li
Engineering 2020, Volume 6, Issue 11, Pages 1302-1314 doi: 10.1016/j.eng.2020.02.011
Keywords: Ubiquitination Phosphoproteome Proteome Dedifferentiation Primary hepatocytes
Title Author Date Type Operation
Effects of Decoction on plasma proteome in cirrhosis: preliminary experimental study with rats
LIU Jie, WANG Jiyao, WEI Liming, LU Ye, Jin Hong
Journal Article
Proteome comparisons reveal influence of different dietary proteins on the development of rat jejunum
Mengjie LI, Chunbao LI, Shangxin SONG, Xinglian XU, Guanghong ZHOU
Journal Article
iTRAQ-based quantitative analysis of cancer-derived secretory proteome reveals TPM2 as a potential diagnostic
Yiming Ma,Ting Xiao,Quan Xu,Xinxin Shao,Hongying Wang
Journal Article
Discovery of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic resonance imaging and omics
Journal Article